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SASInstitute A00-282 Exam Syllabus Topics:

SectionWeightObjectives
Clinical Trials Data Structures10%- Define.xml and dataset specifications
- Clinical domain structures
- CDISC standards: SDTM, ADaM
Clinical Trials Process5%- Clinical trial lifecycle and protocol
- Derive programming requirements from protocol and CRF
Regulatory Submissions5%- ICH and FDA guidelines
- Compliance for clinical data reporting
Validate Clinical Trial Data Reporting20%- Use PROC COMPARE and log review
- Programming validation techniques
- Validation principles
Manage Clinical Trials Data5%- Access and explore clinical datasets
- Clean, merge, and subset data
- Use SQL and dictionary tables
Report Clinical Trials Results10%- PROC REPORT and PROC PRINT
- Produce tables, listings, and figures
Apply Statistical Procedures for Clinical Trials15%- Basic statistical analysis for clinical data
- PROC MEANS, FREQ, TABULATE
Transform or Summarize Clinical Trials Data15%- Aggregation and transposition
- Derive variables and study days
- Data step manipulation
Macro Programming for Clinical Trials15%- Debugging macros
- Macro variables and parameters
- Create and call macros

SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:

1. Given the SAS data set WORK.VS1:

Which value will be assigned to variable TOTAL?

A) 140
B) missing
C) 560
D) 112


2. This question will ask you to provide a line of missing code. Given the data set RAWBP that is sorted by SUBJECT TEST WEEK:

The following SAS program is submitted:
data bp;
set rawbp;
by subject test week;
retain baseline;
if first.test then baseline = .;
if week = 0 then baseline = value;
else if week > 0 then do;
<insert code here>
end;
run;
Which statement must be added to the program to calculate percent change from baseline?

A) pct_chg = ((value - baseline) /baseline)*100;
B) pct_chg = ((baseline - value) /baseline)*100;
C) pct_chg = ((value - baseline) /value)*100;
D) pct_chg = ((baseline - value) /value)*100;


3. Vital Signs are a component of which SDTM class?

A) Special Purpose
B) Events
C) Interventions
D) Findings


4. The print below shows the first four observations from the TEST2 dataset.
Variable names are given in the first row.

The statistical analysis plan (SAP) requests that a two sample t-test be performed to compare the mean of variable FINALBP for levels of the variable TRT.
You review the following code from a colleague:
proc ttest data=test2;
by trt;
var finalbp;
run;
This code does not produce the analysis requested by the SAP.
What is wrong with this code?

A) Variable FINALBP should be specified on a TWOSAMP statement instead of a VAR statement.
B) Variable TRT should be specified on a CLASS statement instead of a BY statement.
C) Variable TRT should be specified on a WEIGHT statement instead of a BY statement.
D) Variable FINALBP should be specified on a TEST statement instead of a VAR statement.


5. The following SAS program is submitted:

What is the value of the variable day when the data step completes?

A) 1
B) 8
C) 6
D) 7


Solutions:

Question # 1
Answer: A
Question # 2
Answer: A
Question # 3
Answer: D
Question # 4
Answer: B
Question # 5
Answer: B

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